MVP

Contact: (0191) 2563536/2563682 - Day Unit ward 36

This information sheet is offered as a guide to you and your family. Your treatment will be fully explained by your doctor or nurse, who will be happy to answer any questions.
Treatment: Your doctor has prescribed for you a treatment known as MVP, which consists of the following chemotherapy drugs: -

Mitomycin C, Vinblastine, Cisplatin

These drugs are administered in the form of an intravenous injection via a ‘drip’ into a vein in your arm and may be administered as either in patient or day case treatment.
You will be asked to attend the unit every three weeks for this treatment, up to a maximum of six cycles.

As each patient is an individual your experience will be different to other patients receiving chemotherapy. Common side effects that you may experience during treatment are:

Nausea and vomiting (sickness)
The severity of any nausea and vomiting will vary from person to person. An antisickness injection will be administered prior to your chemotherapy. You will also be given
some anti-sickness tablets to take home. If you continue to feel sick, contact the ward or your GP as your anti-sickness medication may need to be changed or increased. It is extremely important that you always drink 2 litres + of fluid per day to maintain healthy kidney function needed to continue your treatment.

Bone Marrow Suppression
Your bone marrow is where your blood cells are made (these are the red cells, white cells, and platelets) to replace those naturally worn out by the body. Chemotherapy
interferes with this process and the number of the cells in your blood can become lower than normal. This means following your treatment you could become:

• Prone to infection: White cells fight infection, a low white count can make you prone to infection. You may develop a sore throat, cough, high temperature, shivering or
other symptoms, which may be due to infection.
If you develop a high temperature, shivering or any symptoms, which may be due to an infection, immediately contact your GP or NCCT.

A raised temperature is:

Above 38C (100.4F) at any time or
Above 37.5C (99.5F) at any two readings, taken an hour or more apart.

• Anaemia: Red cells carry oxygen around your body, a shortage of these cells is called anaemia. You may feel dizzy, out of breath or unusually tired and you may
look pale.

• Prone to bleeding: Platelets help to clot your blood and slow down bleeding. A low platelet count may make you prone to bleeding, this usually takes the form of nosebleeds, bruising or bleeding gums.
You will have a routine blood test prior to each treatment to monitor the effects of the chemotherapy. Please contact your GP or the unit if you experience any of these symptoms.

Fluid Intake
Cisplatin can cause kidney damage if fluid intake is poor. It is very important that you drink a minimum of 2 litres each day every day when you are at home in between
treatments. If nausea or vomiting prevents you doing this you must inform your doctor or your ward as soon as possible.

Hair loss
During your treatment hair loss is not usual although you may experience some thinning of your hair, should this thinning be excessive a wig can be arranged. Please remember this is a temporary side effect and your hair should return to normal at the end of your treatment.

Tingling or numbness in fingers and toes
Occasionally, loss of feeling, tingling and numbness of the hands and feet may occur. This is usually temporary and may decrease over several months when your treatment is completed. If you experience any of these symptoms please report them to your doctor or nurse.

Hearing Loss
One of the drugs in your regime, Cisplatin, can occasionally cause hearing loss. If during treatment you become aware of any difference in your hearing ability please report this to your consultant.

Constipation
Occasionally this treatment can cause constipation. If this becomes a problem please inform your nurse or doctor so appropriate treatment can be given.

Extravasation
The drugs you are about to receive are known as “ cytotoxic “ or “chemotherapy” drugs. Very few of these drugs may be given by mouth and most need to be administered
directly into the blood stream through a plastic needle inserted directly into a vein, this needle is known as a cannula. It is therefore very important that good venous access is found (a good vein in which to put the cannula) so that chemotherapy may be given directly into a vein. It should not cause pain on administration and often the only
sensation you may experience is a “coldness “ running up your arm. If the drip had displaced itself from the vein an “extravasation” could occur where chemotherapy is
administered outside the vein, causing damage to the surrounding tissues. This happens very rarely. Indications are pain around the cannula site, redness or swelling. Your nurse will of course be looking for any signs of extravasation throughout the time your chemotherapy is in progress but it is essential that you inform your nurse if problems arise. Very occasionally patients may notice pain and discomfort around the area only after their chemotherapy has been completed. This also must be reported immediately so that appropriate treatment may be prescribed.

Fatigue
Many people feel tired and have low energy levels whilst undergoing chemotherapy. There is very little you can do to avoid this but research has shown that patients who
suffer fatigue need to take gentle exercise and rest often. This feeling of fatigue is quite normal and energy levels will begin to improve once treatment is completed.
Please remember side effects are usually temporary. If you experience any of them, discuss them with your doctor or nurse.

If you have any questions or concerns regarding your treatment please contact:

Mon-Thurs 8.00am - 6.00pm Day Unit ward 36 tel. 0191 2563536/2563682
Friday 8.00am - 4.30pm
Outside these hours Wards 37/38 tel. 0191 2563537/2563538

N.B. If you require further information regarding the drugs you receive British Association of Cancer United Patients and their Families and Friends (BACUP) produce an in
formation booklet free of charge. The telephone number is Freephone 0808 800 1234.