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Introduction Show [+]Hide [-]

This information sheet is a guide to you and your family. Your treatment will be fully explained by your doctor or nurse, who will be happy to answer any questions.
Your Treatment: Your doctor has prescribed for you a treatment known as PVACEBOP. This is a combination of drugs taken by mouth and drugs given as injections
given over a four week cycle (day 1 to day 28.) Some drugs may be taken at home but others other require a visit to hospital. The treatment consists of the following
chemotherapy drugs:-

Day 1 Vinblastine injection
Day 1 Etoposide infusion
Day 2+3 Etoposide capsules
Day 1 to 14 Procarbazine capsules
Day 1 to 14 Chlorambucil tablets
Day 8 Doxorubicin injection (also called Adriamycin)
Day 8 Vincristine Injection
Day 14 to 28 Prednisolone tablets
Day 15 Bleomycin injection
Day 28 Bleomycin injection.
Day 1, day 8, day 15 and day 28
treatments require a visit to hospital. Of these drugs, vinblastine, doxorubicin, Vincristine and bleomycin are administered as short intravenous injections via a ‘drip’ into a vein in your arm. Etoposide is also given into a vein in your arm but is given as a slow infusion (drip)

Day 2+3 Etoposide and Procarbazine, chlorambucil and prednisolone are administered orally i.e. by mouth and can be taken at home.
Prednisolone tablets should be taken with food and not on an empty stomach as they may cause indigestion. They may also cause an increase in appetite. It is better to take them earlier in the day – with breakfast and lunch – since they can make you feel more alert and prevent sleep.
Chlorambucil tablets must be stored in the fridge. Keep out of the reach of children. You will have a routine blood test before each treatment to monitor the effects of the chemotherapy.

How long will I be in the department?
Time in the department will vary depending on which week of your cycle you are having.

Can I bring someone with me?
Yes you may also wish to bring some items to pass the time e.g. books, personal stereos.

Do I need to take any special precautions before I come to the day unit?
You can eat and drink as usual. You can also take any medication that has been prescribed by your GP providing you have told your hospital doctor you are taking this medication. A packed lunch will be provided.

Will I be able to drive home?
Yes it is extremely uncommon for people to feel unwell immediately after their treatment.

Common side effectsShow [+]Hide [-]

As each patient is an individual your experience will be different to other patients receiving chemotherapy. Common side effects that you may experience during treatment are:

• Nausea and vomiting (sickness)
The severity of any nausea and vomiting will vary from person to person. An anti-sickness injection will be administered prior to your chemotherapy. You will also be given some antisickness tablets to take home. If you continue to feel sick, contact the day unit as your anti-sickness medication may need to be changed or increased.

• Sore Mouth
Following treatment you may develop a sore mouth and may notice mouth ulcers. Very hot spicy foods should be avoided. To help prevent oral infections brush your teeth regularly (at least twice a day) and drink plenty of fluids. To prevent any mouth ulcers becoming infected you should use an anti-bacterial mouthwash. Ask your doctor or nurse to recommend one that is suitable. Occasionally during treatment you may experience a strange taste sometimes described as a metallic or bitter. A strong flavoured sweet or mint may help disguise this.

• Bone Marrow Suppression
Your bone marrow is where your blood cells are made (these are the red cells, white cells, and platelets) to replace those naturally worn out by the body. Chemotherapy interferes with this process and the number of the cells in your blood can become lower than normal. This means following your treatment you could become:

• Prone to infection: White cells fight infection. A low white count can make you prone to infection. You may develop a sore throat, cough, high temperature, shivering or other symptoms, which may be due to infection. A normal temperature is between 36°C and
37°C. A raised temperature is:

Above 38°C (100.4F) at any time or
Above 37.5°C (99.5F) at any two readings taken an hour apart.

• Anaemic: Red cells carry oxygen around your body. A shortage of these cells is called anaemia. You may feel dizzy, out of breath or unusually tired and you may look pale.

• Prone to bleeding: Platelets help to clot your blood and slow down bleeding. A low platelet count may make you prone to bleeding, this usually takes the form of nose-bleeds, bruising or bleeding gums.
You will have a routine blood test prior to each treatment to monitor the effects of the chemotherapy. Please contact Ward 6b or Ward 8 if you experience any of these symptoms.

• Hair loss
Unfortunately as a result of your treatment you will experience hair loss. The hair falls out gradually 10 to 14 days following your first course of treatment. The time scale varies from person to person. Please remember that this is a temporary side effect and your hair will grow back when your treatment is completed. Your nurse will arrange for you to be provided with a wig if required. A scalp cooling service to prevent or reduce hair loss is available in this trust but is located at the Northern Centre for Cancer Treatment (NCCT).
If you wish to have further details please ask your nurse or doctor.

• Flu-like symptoms & headaches
One of your injections called bleomycin may cause flu-like symptoms such as fever, aches and pains and shivering about three to five hours after it is given. These symptoms are temporary and should go within 12 to 24 hours. Paracetamol will help. If your symptoms are particularly severe, tell your doctor on your next visit.

• Sex, pregnancy and family planning
If you are having chemotherapy it doesn’t mean that you shouldn’t have sex, but you may not feel like it. If there is a chance of pregnancy, you must use effective contraception while on chemotherapy. If you suspect that you or your partner may be pregnant please tell your doctor immediately. Chemotherapy may affect your ability to have children in the future – please discuss this with your doctor or chemotherapy nurse before treatment.

• Fatigue
Many people feel tired and have low energy levels whilst undergoing chemotherapy. There is very little you can do to avoid this but research has shown that patients who suffer fatigue need to take gentle exercise and rest often. This feeling of fatigue is quite normal and energy levels will begin to improve once treatment is completed.
Please remember side effects are usually temporary. If you experience any of them, discuss them with your doctor or nurse.

• Tingling or numbness in fingers and toes
Occasionally, loss of feeling, tingling and numbness of the hands and feet may occur. This is usually temporary and may decrease over several months when your treatment is completed. If you experience any of these symptoms please report them to your doctor or nurse.

• Discoloured urine.
Doxorubicin because of its red colour, may discolour your urine red or pink for the first few times following treatment. This is perfectly normal and nothing to worry about.

• Nail ridging
The chemotherapy can cause your fingernails to develop ridges. This is temporary and the ridging will grow out.

• Constipation
Try to drink plenty of fluids and eat foods high in fibre such as fruits and cereals. Report this to your hospital doctor who may prescribe a suitable laxative.

• Skin colouring
Sometimes as a result of the chemotherapy, your skin may appear darker in colour, especially around the joints. This is known as hyperpigmentation. The skin will return to normal when treatment is finished.

• Heart damage
Adriamycin (Doxorubicin) may be harmful to your heart. However there is an established safe maximum dose and your treatment will stay well within this. As a precaution your doctor may arrange for you to have an ECG (heart tracing) or other heart tests to check your heart before your treatment.

• Extravasation
The drugs you are about to receive are known as “cytotoxic “ or “chemotherapy” drugs. Most of these drugs need to be administered directly into the blood stream through a cannula (a plastic needle inserted directly into a vein.) In most cases it should not cause pain on administration and often the only sensation you may experience is a “coldness “ running up your arm. However if the drip becomes dislodged from the vein an “extravasation” could occur with chemotherapy leaking outside the vein, causing damage to the surrounding tissues. This happens very rarely. Indications of this are pain, redness or swelling around the cannula site. Your nurse will be looking for any signs of extravasation while your chemotherapy is in progress but it is essential that you inform your nurse if problems arise. Very occasionally patients may notice pain and discomfort around the area only after their chemotherapy has been completed. This also must be reported immediately so that appropriate treatment may be prescribed.

After your TreatmentShow [+]Hide [-]

Alcohol must be avoided during treatment with Procarbazine as a strong reaction is likely to occur. Alcohol is best avoided for 48 hours after completing each course of treatment.

Contact numbers

If you have any questions or concerns regarding your treatment please

  • Ward 6b (Monday – Friday, 8.00am – 5.00pm) - tel: 0191 282 4388
  • Ward 8 (Available at all times) - tel: 0191 282 5008

Further information

For further information regarding the drugs you receive, contact Macmillan Cancer Support.

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