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Musculoskeletal Services

Self Injection Of Methotrexate

Methotrexate is the drug used to slow down and control your arthritis. It belongs to a group of drugs called cytotoxic agents. It is therefore necessary to take precautions and handle with care when administering the injection.

A trained nurse will explain the process of injecting methotrexate and teach you how.

You will not be expected to do it yourself until you feel confident. If at any time you decided you do not want to carry on – do not worry, we can give you an alternative injection.

It is important whilst taking methotrexate that you continue to have regular blood tests and monitoring to check for any side effects. The nurse will inform you how often. If  you experience any problems the 24-hour help line number is below.

Remember Do Not Inject If:

  • You think you are pregnant
  • You have an infection or feel unwell
  • You have not had a blood test within the last 8 weeks

Some Points To Remember When Handling Methotrexate

  • Do not handle if pregnant or breast-feeding
  • Use effective contraception
  • Alcohol should be kept to a minimum.
  • Remember to attend the monitoring clinic regularly for blood tests to monitor safely and effects of Methotrexate


0191 2231109 – Musculo Skeletal Out-Patients
0191 233 6161 ext 97020 – Ward 20

There is always someone available to talk to you if you experience any problems

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